原标题：饲喂有机酸和中链脂肪酸混合物可降低灌服产肠毒素埃希氏大肠杆菌K88的仔猪腹泻
Feeding the blend of organic acids and medium chain fatty acids reduces the diarrhea in piglets orally challenged with enterotoxigenic Escherichia coli K88
作者：Xin Jian Leia, Jae Won Parka, Dong Heon Baekb, Jong Keun Kimaand In Ho Kima*
aDepartment of Animal Resource and Science, Dankook University, Cheonan, Chungnam
330-714, South Korea bDepartment of Oral Microbiology and Immunology, Dankook University, Cheonan, Chungnam 330-714, South Korea
来源：j.anifeedsci.2016.11.016
翻译：肠动力研究院 梁琦
【创新点】评估了有机酸（OAs）和中链脂肪酸（MCFAs）的混合物对攻毒产肠毒素埃希氏大肠杆菌K88断奶仔猪的生长性能和腹泻率的影响。
攻毒产肠毒素埃希氏大肠杆菌K88断奶仔猪，有机酸（OAs）和中链脂肪酸（MCFAs）的混合物提高了生长性能。
有机酸（OAs）和中链脂肪酸（MCFAs）的混合物减少断奶后腹泻发生率。
【摘要】本研究进行了为期3周的实验，来评估有机酸（OAs）和中链脂肪酸（MCFAs）混合物对产肠毒素埃希氏大肠杆菌K88攻击的断奶仔猪的生长性能和腹泻发生率的影响。30只断奶仔猪（28±1d，6.24±0.36 kg）被随机分成3个处理组，每组5个重复（每栏2头仔猪）。实验分组如下：（1）对照组：基础日粮（CON）;（2）BOM1组：CON + 0.2％的OAs和MCFAs混合物;（3）BOM2组:CON + 0.4％的OAs和MCFAs混合物。实验第8-10天，每天用注射器给仔猪灌服5mL产肠毒素埃希氏大肠杆菌K88（109CFU / mL）。实验结果显示，在实验的第7,14和21天，饲喂含有OAs和MCFAs混合物日粮的仔猪体重（BW）要显著高于喂食CON日粮的仔猪体重（P <0.05）。在用产肠毒素埃希氏大肠杆菌K88攻击前后，日粮中添加OAs和MCFAs混合物能够显著提高断奶仔猪的平均日增重（ADG），平均日采食量（ADFI），和除第8-14天外的肉料比（G:F）（P <0.05）。此外，在第1-21天，饲喂BOM2日粮的仔猪的最终体重（BW）（P <0.05）和ADG要比喂食BOM1日粮的仔猪更高。在攻击前和攻击后（第8-14天），BOM1组和BOM2组仔猪的腹泻率要显著低于CON组（P <0.05）。然而，在第15-21天，仔猪腹泻率不受处理组差异的影响（P> 0.05）。研究结果表明：日粮中添加0.2％或0.4％的OAs和MCFAs混合物能够提高断奶仔猪的生长性能和减少断奶后仔猪腹泻（灌服产肠毒素埃希氏大肠杆菌K88的断奶仔猪的腹泻发生率降低）。
【关键词】腹泻；产肠毒素型大肠杆菌K88；生长性能；中链脂肪酸；有机酸；断奶仔猪；
以下是实验中相关图表
表1：基础日粮的组成和营养水平（作为喂食基础）
表2：有机酸（OA）和中链脂肪酸（MCFAS）的混合物对用产肠毒素型大肠杆菌K88攻击的断奶仔猪生产性能的影响
表3：有机酸（OA）和中链脂肪酸（MCFAS）的混合物对用产肠毒素型大肠杆菌K88攻击的断奶仔猪腹泻发生率的影响
Highlights
We assessed the effect of the blend of organic acids (OAs) and medium chain fatty acids (MCFAs) on the growth performance and diarrhea scores in weanling pigs challenged with enterotoxigenic Escherichia coli K88.
The blend of OAs and MCFAs improved growth performance piglets that orally challenged with enterotoxigenic Escherichia coli K 88.
The blend of OAs and MCFAs reduced post-weanling diarrhea incidence.
Abstract
A 3-wk experiment was conducted to determine the effect of the blend of organic acids (OAs) and medium chain fatty acids (MCFAs) on the growth performance and diarrhea incidence in weanling pigs challenged with enterotoxigenic Escherichia coli K88. Thirty weaned pigs (28 ± 1 d of old, 6.24 ± 0.36 kg) were used in a randomized complete block design experiment with 3treatments, 5 replicate pens per treatment and 2 animals per pen. The treatments were: (1) control, basal diet (CON); (2) CON + 0.2% blend of OAs and MCFAs (BOM1); 3) CON + 0.4% blend of OAs and MCFAs (BOM2). From d 8 to 10, pigs were orally challenged with 5 mL enterotoxigenic Escherichia coli K88 (109 CFU/mL). Pigs fed the blend of OAs and MCFAs diets had greater (P < 0.05) body weight (BW) than pigs fed CON diet on d 7, 14 and 21of the experiment. During pre- and post-challenge, the inclusion of the blend of OAs and MCFAs increased (P < 0.05) average daily gain (ADG), average daily feed intake (ADFI) and gain to feed ratio (G:F) with the exception of G:F during d 8 to 14. Additionally, pigs fed BOM2 diet had higher (P < 0.05) final BW and ADG during d 1 to 21than those fed BOM1 diet. Before challenge and post-challenge (d 8 to 14), incidence of diarrhea was lower (P < 0.05) in BOM1 and BOM2 treatments than that in CON treatment. However, diarrhea incidence was not affected by dietary treatments between d 15 and 21 (P > 0.05). Results indicated that dietary supplementation with the blend of OAs and MCFAs at 0.2% or 0.4% improved growth performance and reduced diarrhea as indicated by reduced diarrhea incidence in weanling piglets that orally challenged with enterotoxigenic Escherichia coli K88
Keywords: diarrhea; enterotoxigenic Escherichia coli K88; growth performance; medium chain
fatty acids; organic acids; weanling piglets
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