Utilization of Medium-Chain Triglycerides by Neonatal Piglets:I.Effects on Milk Consumption and Body Fuel Utilization

作者：N.J. Benevenga ^2,3,J.K.Steinman-Goldsworth²,T.D.Creshaw2 and J.Odle 2,3

University of Wisconsin, Madison 53706

来源：J. Anita. Sci. 1989. 67:3331-3339

翻译：肠动力研究院

【摘要】用初生仔猪开展了2次实验。第一个实验中，共使用18头仔猪评估口服0，12ml，24ml 中链脂肪酸甘油酯（MCT）对随后的母乳吸收的影响。体重-吮乳量-体重实验结论显示：强饲24ml的MCT显著降低了(P <0 .05) 吮乳量，但是强饲12ml确没有影响吮乳量。在第二个实验中，两组实验（每组24头仔猪）用来评估饲喂12ml的MCT和12ml的MCT+6mmol的L-肉毒碱在0，12小时，24小时对血糖、血铵氮和尿氮浓度的影响；饲喂处理后24小时对肝脏和股二头肌葡糖糖浓度的影响。仔猪饲喂MCT显著降低(P <0 .05)了血液尿素氮。各处理组的血铵氮和血糖浓度差异不显著(P >0 .10) 。在实验一中，饲喂MCT的处理组的仔猪肝糖元的减少幅度非常小(P <0 .05)，但是在第二个实验中这种情况没有重复。总之，补充肉毒碱对MCT处理组无额外的影响。本实验的结果显示：初生仔猪利用MCT作为机体能量来源；MCT的添加可节省一些重要的在出生前储存在机体内的能量、葡萄糖和蛋白。

【关键词】初生动物 仔猪 中链脂肪酸甘油酯 血液尿素 能量代谢

 以下是实验中相关图表    

表1 饲喂初生仔猪中链脂肪酸甘油酯研究的实验计划（实验1和实验2）

表2 初生仔猪口服中链脂肪酸甘油酯10小时之后对母乳吸收量的影响

表3 仔猪饲喂中链脂肪酸甘油酯对血液尿素氮浓度的影响

表4 仔猪饲喂中链脂肪酸甘油酯对屠宰时机体、肝脏或股二头肌重量和24小时重量损失的影响

表5 饲喂和不饲喂中链脂肪酸甘油在出生时和24小时后组织葡萄糖浓度

表6 仔猪出生时总肝糖元和饲喂中链脂肪酸甘油酯对肝糖元损失的影响

表7 初生仔猪不同机体组成成分的估算能量浓度

 实际意义

    弱仔、体重小的仔猪极易死亡。这些仔猪出生时机体能量储备有限。一般在仔猪出生12小时内口服高能量物质能够增加弱仔的成活率。补充的能量须能够帮助机体保留自身的能量储备，能够作为机体维持体温的能量。补充道能量须帮助仔猪在群体中建立自己的地位。
 

Abstract

Two experiments were conducted utilizing neonatal piglets. In the first experiment, 18 piglets were used to determine the effect of an oral supplement of 0, 12 or 24 ml of a medium-chain triglyceride (MCT) product on subsequent milk consumption. Results from the weigh-suckle-weigh experiment showed that force-feeding 24 ml of the MCT decreased (P < .05) milk intake but 12 ml did not. In the second experiment, two trials (each with 24 piglets) were used to investigate the effect of 12 ml of MCT or 12 ml .of MCT plus .6 mmol of L-carnitine on the concentration of blood glucose, ammonium N and urea N at 0,

12 or 24 h and liver and biceps femoris glycogen at 24 h post-treatment. Blood urea N decreased (P < .05) in piglets receiving the MCT. Blood ammonium N and glucose concentrations were not different (P > .10) among treatments. In Trial 1, the predicted loss of liver glycogen was less (P < .05) in pigs given the MCT treatments, but this response was not repeated in the second trial. In general, supplemental camitine provided no added benefit over the MCT treatment alone. The results from this study indicate that MCT is utilized as a fuel by the newborn piglet and that its use may spare critical fuels, glycogen and protein, that were stored in the piglet prior to birth.

Keywords:Newborn Animals, Piglets, Medium-Chain Triglyceride, Blood Urea, Energy Metabolism.)

Implications

Small, weak piglets have the greatest risk of death. These piglets are most likely to be born with limited body energy reserves. The use of an oral high-energy supplement that can be given at the time the litter is processed (usually within 12 h of birth) should enhance the probability of survival of these piglets. The

supplemental energy should help conserve body energy reserves and provide a source of energy for the maintenance of body tempera- ture~ The supplemental energy should help the piglet establish itself as a viable member of the litter. 


 

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